Classification of alpha 1-adrenoceptor subtypes.

  title={Classification of alpha 1-adrenoceptor subtypes.},
  author={Martin C Michel and Barry A. Kenny and Debra A. Schwinn},
  journal={Naunyn-Schmiedeberg's archives of pharmacology},
  volume={352 1},
Two alpha 1-adrenoceptor subtypes (alpha 1A and alpha 1B) have been detected in various tissues by pharmacological techniques, and three distinct cDNAs encoding alpha 1-adrenoceptor subtypes have been cloned. The profile of an increasing number of subtype-selective compounds at cloned and endogenous receptors recently has facilitated alignment between cloned and pharmacologically defined alpha 1-adrenoceptor subtypes. Thus, alpha 1a-adrenoceptors (previously designated alpha 1c), alpha 1b… CONTINUE READING
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