Classification of Polyene Antibiotics According to Chemical Structure and Biological Effects

@article{KotlerBrajtburg1979ClassificationOP,
  title={Classification of Polyene Antibiotics According to Chemical Structure and Biological Effects},
  author={J. Kotler-Brajtburg and G. Medoff and G. Kobayashi and S. Boggs and D. Schlessinger and R. C. Pandey and K. Rinehart},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1979},
  volume={15},
  pages={716 - 722}
}
Fourteen polyene antibiotics and six of their semisynthetic derivatives were compared for their effects on potassium (K+) leakage and lethality or hemolysis of either Saccharomyces cerevisiae or mouse erythrocytes. These polyene antibiotics fell into two groups. Group I antibiotics caused K+ leakage and cell death or hemolysis at the same concentrations of added polyene. In this group fungistatic and fungicidal levels were indistinguishable. Group I drugs included one triene (trienin… Expand
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  • Biochimica et biophysica acta
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TLDR
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TLDR
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