Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti‐inflammatory drugs

@article{Kowalski2013ClassificationAP,
  title={Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti‐inflammatory drugs},
  author={M. L. Kowalski and Ricardo Asero and Sevim Bavbek and Miguel Blanca and Natalia Blanca-L{\'o}pez and Grażyna Bochenek and Knut Brockow and Paloma Campo and Gulfem Elif Celik and Josefina R Cernadas and Gabriele Cortellini and E R Gomes and Ewa Nizankowska-Mogilnicka and Antonino Romano and Andrzej Szczeklik and Sergio Testi and M J Torres and Stefan W{\"o}hrl and Joanna Samanta Makowska},
  journal={Allergy},
  year={2013},
  volume={68},
  pages={1219 - 1232}
}
Hypersensitivity reactions to aspirin (acetylsalicylic acid) and other nonsteroidal anti‐inflammatory drugs (NSAIDs) constitute only a subset of all adverse reactions to these drugs, but due to their severity pose a significant burden to patients and are a challenge to the allergist. In susceptible individuals, NSAIDs induce a wide spectrum of hypersensitivity reactions with various timing, organ manifestations, and severity, involving either immunological (allergic) or nonimmunological… 
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Although able to confirm the presence of a hypersensitivity reaction, an oral or bronchial provocation test should be performed only under the supervision of a skilled physician at a well-equipped institution.
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References

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TLDR
Although able to confirm the presence of a hypersensitivity reaction, an oral or bronchial provocation test should be performed only under the supervision of a skilled physician at a well-equipped institution.
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TLDR
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Abstract:  Aspirin and other nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two
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TLDR
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TLDR
NSAID intolerance might precede the onset of CU by years, and both multiple and single NSAID reactors with a history of aspirin-induced urticaria seem at higher risk for CU than patients with a History of single intolerance to NSAIDs other than aspirin.
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