Classification and evolution of P-loop GTPases and related ATPases.

@article{Leipe2002ClassificationAE,
  title={Classification and evolution of P-loop GTPases and related ATPases.},
  author={Detlef D. Leipe and Yuri I. Wolf and Eugene V. Koonin and L. Aravind},
  journal={Journal of molecular biology},
  year={2002},
  volume={317 1},
  pages={
          41-72
        }
}
Sequences and available structures were compared for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution. The GTPase superclass can be divided into two large classes, each of which has a unique set of sequence and structural signatures (synapomorphies). The first class, designated TRAFAC (after translation… 
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