Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.

@article{Yeoh2002ClassificationSD,
  title={Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.},
  author={E Yeoh and Mary Elizabeth Ross and Sheila Shurtleff and Warren Williams and Divyen H. Patel and Rami Mahfouz and Fred G. Behm and Susana C. Raimondi and Mary V. Relling and Anami R Patel and Cheng Cheng and Dario Campana and Dawn Wilkins and Xiaodong Zhou and Jinyan Li and Huiqing Liu and Ching-Hon Pui and William E. Evans and Clayton W. Naeve and Limsoon Wong and James R. Downing},
  journal={Cancer cell},
  year={2002},
  volume={1 2},
  pages={133-43}
}
Treatment of pediatric acute lymphoblastic leukemia (ALL) is based on the concept of tailoring the intensity of therapy to a patient's risk of relapse. To determine whether gene expression profiling could enhance risk assignment, we used oligonucleotide microarrays to analyze the pattern of genes expressed in leukemic blasts from 360 pediatric ALL patients. Distinct expression profiles identified each of the prognostically important leukemia subtypes, including T-ALL, E2A-PBX1, BCR-ABL, TEL… CONTINUE READING