Classification, Functions, and Clinical Relevance of Extracellular Vesicles

@article{vanderPol2012ClassificationFA,
  title={Classification, Functions, and Clinical Relevance of Extracellular Vesicles},
  author={Edwin van der Pol and Anita N. B{\"o}ing and Paul Harrison and A. Sturk and Rienk Nieuwland},
  journal={Pharmacological Reviews},
  year={2012},
  volume={64},
  pages={676 - 705}
}
Both eukaryotic and prokaryotic cells release small, phospholipid-enclosed vesicles into their environment. Why do cells release vesicles? Initial studies showed that eukaryotic vesicles are used to remove obsolete cellular molecules. Although this release of vesicles is beneficial to the cell, the vesicles can also be a danger to their environment, for instance in blood, where vesicles can provide a surface supporting coagulation. Evidence is accumulating that vesicles are cargo containers… Expand
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References

SHOWING 1-10 OF 374 REFERENCES
Exosomes: immune properties and potential clinical implementations
TLDR
The conclusions of 20 years of studies on the immune properties of exosomes and the most recent advances on their roles and potential uses as markers or as therapeutic tools during pathologies, especially in cancer are described. Expand
Exosomes: extracellular organelles important in intercellular communication.
TLDR
This review focuses on various strategies for purifying exosomes and discusses their biophysical and biochemical properties, and an update on proteomic analysis of exosome from various cell types and body fluids is provided and host-cell specific proteomic signatures are discussed. Expand
Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a dynamic extracellular vesicular… Expand
Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses
TLDR
The current ideas on exosomes and immune responses are focused on their mechanisms of secretion and the use of this knowledge to elucidate the former issue, and on their capacity to vehicle genetic messages. Expand
Exosomes as intercellular signalosomes and pharmacological effectors.
TLDR
Exosome biogenesis and molecular content, interaction with target cells, utilisation as biomarkers, and functional effects in various pathophysiologies are considered in this review. Expand
Membrane vesicles as conveyors of immune responses
TLDR
The role of membrane vesicles, in particular exosomes, in the communication between immune cells, and between tumour and immune cells is focused on. Expand
Exosomes--vesicular carriers for intercellular communication.
TLDR
Exosomes transfer not only membrane components but also nucleic acid between different cells, emphasizing their role in intercellular communication. Expand
Exosomes are released by cultured cortical neurones
TLDR
It is demonstrated, using primary cortical cultures, that neurones and astrocytes can secrete exosomes, and it is shown that exosomal release is regulated by depolarisation, suggesting thatExosomes may have a regulatory function at synapses and could also allow intercellular exchange of membrane proteins within the brain. Expand
Microparticles in cancer.
  • J. Rak
  • Biology, Medicine
  • Seminars in thrombosis and hemostasis
  • 2010
Microparticles (MP) are vesicular structures released from cells upon activation, malignant transformation, stress, or death. MP may be derived from the plasma membrane (shed microvesicles), produced… Expand
Exosomes contain ubiquitinated proteins.
TLDR
It is demonstrated that exosomes contain polyubiquitinated proteins, many of which are not integrated into the membrane and relatively enriched as compared to total cell lysates, suggesting that a subset of polyubanquitinated cytoplasmic proteins is incorporated into the MVB pathway. Expand
...
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