Classically activated macrophages use stable microtubules for matrix metalloproteinase-9 (MMP-9) secretion.

@article{Hanania2012ClassicallyAM,
  title={Classically activated macrophages use stable microtubules for matrix metalloproteinase-9 (MMP-9) secretion.},
  author={Raed Hanania and He song Sun and Kewei Xu and Sofia Pustylnik and Sujeeve Jeganathan and Rene E. Harrison},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 11},
  pages={8468-83}
}
As major effector cells of the innate immune response, macrophages must adeptly migrate from blood to infected tissues. Endothelial transmigration is accomplished by matrix metalloproteinase (MMP)-induced degradation of basement membrane and extracellular matrix components. The classical activation of macrophages with LPS and IFN-γ causes enhanced microtubule (MT) stabilization and secretion of MMPs. Macrophages up-regulate MMP-9 expression and secretion upon immunological challenge and require… CONTINUE READING

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