Classical scrapie transmission in ARR/ARR genotype sheep.


The ARR allele is considered to provide a very strong resistance against classical scrapie infection in sheep. In this study, we report the occurrence of clinical transmissible spongiform encephalopathy in ARR/ARR sheep, following their inoculation by the intracerebral route with a classical scrapie isolate. On first passage, the disease displayed an… (More)
DOI: 10.1099/jgv.0.000861