Classical detection theory and the cryo-EM particle selection problem.

Abstract

Particle selection is an essential but tedious step in the determination of macromolecular structures by single particle reconstruction. This paper presents an automatic, multi-reference particle detection scheme that is based on the classical matched filter principle. It makes use of a pre-whitening filter to standardize the noise, a reduced representation… (More)

Cite this paper

@article{Sigworth2004ClassicalDT, title={Classical detection theory and the cryo-EM particle selection problem.}, author={Fred J. Sigworth}, journal={Journal of structural biology}, year={2004}, volume={145 1-2}, pages={111-22} }