Classical crosses of common carp (Cyprinus carpio L.) show co-segregation of antibody response with major histocompatibility class II B genes.

@article{Rakus2009ClassicalCO,
  title={Classical crosses of common carp (Cyprinus carpio L.) show co-segregation of antibody response with major histocompatibility class II B genes.},
  author={Krzysztof Ł. Rakus and Ilgiz Irnazarow and Maria Forlenza and Ren{\'e} J M Stet and Huub F J Savelkoul and Geert Frits Wiegertjes},
  journal={Fish & shellfish immunology},
  year={2009},
  volume={26 3},
  pages={352-8}
}
In cyprinids, two paralogous groups of major histocompatibility (MH) class II B genes, DAB1 and DAB3, have been reported but have not been studied in detail. In our study on MH association with immune responsiveness in common carp (Cyprinus carpio L.) we have taken a long-term approach using divergent selection for antibody production. We report the co-segregation of Cyca-DAB1-like and Cyca-DAB3-like genes with antibody response, in backcrosses to high- and low-responsive parental carp lines… CONTINUE READING
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