Classical conditioning-induced changes in low-molecular-weight GTP-binding proteins in rabbit hippocampus.

Abstract

Classical conditioning of Hermissenda, involving paired light-rotation events, results in a 30-35% decrease in the levels of a 20-kDa G protein (cp20). To test whether a similar protein exists in vertebrates, rabbits were trained to associate a tone with periorbital electrical stimulation and G proteins were analyzed by photoaffinity labeling with [alpha-32P]GTP-azidoanilide. A 20-kDa G protein similar to cp20 decreased by 36% in the hippocampus of rabbits subjected to paired tone and electrical stimulation, but not in unpaired controls. Learning-specific decreases were also found in the amount of ras protein.

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@article{Nelson1991ClassicalCC, title={Classical conditioning-induced changes in low-molecular-weight GTP-binding proteins in rabbit hippocampus.}, author={Thomas J . Nelson and Juan Vicente S{\'a}nchez-Andr{\'e}s and Bernard G. Schreurs and Daniel L. Alkon}, journal={Journal of neurochemistry}, year={1991}, volume={57 6}, pages={2065-9} }