Classical cadherins control nucleus and centrosome position and cell polarity

@inproceedings{Dupin2009ClassicalCC,
  title={Classical cadherins control nucleus and centrosome position and cell polarity},
  author={Isabelle Dupin and Emeline Camand and Sandrine Etienne-Manneville},
  booktitle={The Journal of cell biology},
  year={2009}
}
Control of cell polarity is crucial during tissue morphogenesis and renewal, and depends on spatial cues provided by the extracellular environment. Using micropatterned substrates to impose reproducible cell-cell interactions, we show that in the absence of other polarizing cues, cell-cell contacts are the main regulator of nucleus and centrosome positioning, and intracellular polarized organization. In a variety of cell types, including astrocytes, epithelial cells, and endothelial cells… CONTINUE READING

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