Classical and channel-like urate transporters in rabbit renal brush border membranes.

@article{Knorr1994ClassicalAC,
  title={Classical and channel-like urate transporters in rabbit renal brush border membranes.},
  author={B. Garthoff A. M. Knorr and John C. Beck and Ruth G. Abramson},
  journal={Kidney international},
  year={1994},
  volume={45 3},
  pages={727-36}
}
The precise mechanism by which urate is transported across rabbit renal proximal tubule luminal membranes has not been defined. To determine whether urate flux across this membrane represents simple diffusion or transport on specific carriers, urate uptake was examined in brush border membrane vesicles that were prepared by a Mg+(+)-aggregation technique and then exposed to CuCl2. Na(+)-independent, voltage sensitive urate transport was demonstrated in these Cu+(+)-exposed vesicles. Transport… CONTINUE READING
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