Classical and Alternative NFk B Activation Pathways and Their Roles in Lymphoid Malignancies

@inproceedings{Nishikori2006ClassicalAA,
  title={Classical and Alternative NFk B Activation Pathways and Their Roles in Lymphoid Malignancies},
  author={Momoko Nishikori},
  year={2006}
}
Nuclear factor-kB (NF-kB) is a family of highly regulated dimeric transcription factors that play pivotal roles in inflammatory responses and immunological reactions. Although they are often activated concurrently, classical and alternative NF-kB activation pathways have distinct regulatory functions, producing secondary inflammatory responses and regulating lymphoid organ development, respectively. As NF-kB functions in the proliferation, differentiation, and survival of lymphocytes, increased… CONTINUE READING

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