Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity.

@article{Abate2012ClassesOS,
  title={Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity.},
  author={Carmen Abate and Roberto Perrone and Francesco Berardi},
  journal={Current pharmaceutical design},
  year={2012},
  volume={18 7},
  pages={
          938-49
        }
}
Although several pieces of information are still missing about sigma-2 (σ2) receptor, the production of high affinity 2 receptor ligands allowed important acquisitions. Morphans such as CB64D and CB184 were the first truly σ2-selective ligands synthesized, and their use in cell cultures highlighted the relationship between σ2 receptors and cell… CONTINUE READING