Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

@article{Muramatsu2000ClassSR,
  title={Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme},
  author={M. Muramatsu and K. Kinoshita and S. Fagarasan and S. Yamada and Y. Shinkai and T. Honjo},
  journal={Cell},
  year={2000},
  volume={102},
  pages={553-563}
}
  • M. Muramatsu, K. Kinoshita, +3 authors T. Honjo
  • Published 2000
  • Biology, Medicine
  • Cell
    • Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching from IgM to IgA without cytokine stimulation. AID deficiency caused a complete defect in class switching and showed a hyper-IgM phenotype with enlarged germinal centers containing strongly activated B cells before or after immunization. AID-/- spleen cells stimulated in vitro with LPS and cytokines failed to undergo class switch recombination although they expressed germline transcripts. Immunization of AID… CONTINUE READING
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