Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

@article{Muramatsu2000ClassSR,
  title={Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme},
  author={Masamichi Muramatsu and Kazuo Kinoshita and Sidonia Fagarasan and Shu-ichi Yamada and Yoichi Shinkai and Tasuku Honjo},
  journal={Cell},
  year={2000},
  volume={102},
  pages={553-563}
}
View on Elsevier
cell.com
3,241 Citations
Highly Influential Citations
300
Background Citations
1,302
Methods Citations
150
Results Citations
34

Figures and Tables from this paper

3,241 Citations

Citation Type

Citation Type

Activation-Induced Cytidine Deaminase Initiates Immunoglobulin Gene Conversion and Hypermutation by a Common Intermediate
TLDR
It is shown that the stepwise removal of the ψV donors not only reduces and eventually abolishes Ig gene conversion, but also activates AID-dependent Ig hypermutation, which strongly supports a model in which AID induces a common modification in the rearranged V(D)J segment.
Brief Definitive Report Activation-induced Deaminase (aid)-directed Hypermutation in the Immunoglobulin S ␮ Region: Implication of Aid Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation
Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region
TLDR
It is reported that B cell stimulation which induces CSR but not SHM, leads to AID-dependent accumulation of SHM-like point mutations in the switch μ region, uncoupled with CSR, which strongly suggest that AID itself or a single molecule generated by RNA editing function of AID may mediate a common step ofSHM and CSR.
Activation-induced cytidine deaminase mediates central tolerance in B cells
TLDR
It is demonstrated that low levels of AID in bone marrow immature and transitional B cells suppress the development of autoreactivity, and in vitro, AID deficient immature/transitional B cells are significantly more resistant to anti-IgM–induced apoptosis than their normal counterparts.
Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
TLDR
It is shown that recessive mutations of the gene encoding uracil–DNA glycosylase (UNG) are associated with profound impairment in CSR at a DNA precleavage step and with a partial disturbance of the SHM pattern in three patients with hyper-IgM syndrome.
Negative regulation of activation-induced cytidine deaminase in B cells.
  • T. Muto, I. Okazaki, T. Honjo
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
Conditional AID-transgenic mice are generated that constitutively express AID only in B cells, possibly providing an explanation for the absence of deregulation of CSR and SHM in AID -transgenic B cells.
Recombinogenic Phenotype of Human Activation-Induced Cytosine Deaminase
TLDR
The initial step of base excision repair is required for AID-dependent recombination and is a branch point for either hypermutagenesis or recombination.
Activation-induced deaminase in B lymphocyte maturation and beyond.
Activation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-editing enzyme-catalytic (APOBEC) family, deaminates DNA cytidines into uridines and is the major trans-acting player of…
Controlling somatic hypermutation in immunoglobulin variable and switch regions
TLDR
There is an intricate interplay between faithful DNA repair and mutagenic DNA repair during somatic hypermutation, in that some proteins from accurate repair pathways are also involved in mutagenesis.
Activation-Induced Cytidine Deaminase Does Not Impact Murine Meiotic Recombination
TLDR
It is concluded that AID has a minor impact, if any, on the overall frequency of meiotic recombination, and the frequency of recombination in the female germline was greater than in male germline.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 165 REFERENCES
Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)
Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*
TLDR
Findings suggest that AID is a new member of the RNA-editing deaminase family and may play a role in genetic events in the germinal center B cell.
Efficient recombination of a switch substrate retrovector in CD40-activated B lymphocytes: implications for the control of CH gene switch recombination.
TLDR
It is shown that cultures of purified murine and human B cells, stimulated only by CD40 receptor engagement, possess a potent switch recombinations activity and the efficiency of switch recombination with SSRs resembles that seen for endogenous C(H) class switching.
High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells.
TLDR
It is found that the extents of methylation and the amounts of germline transcripts do not necessarily correlate with the efficiency of recombination in induced CH12F3 cells, leading to the proposal that switch recombination can be separated into at least two phases.
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
Somatic hypermutation in the heavy chain locus correlates with transcription.
Shutdown of class switch recombination by deletion of a switch region control element
TLDR
Recombination to a particular switch region was abolished in mice that were altered to lack sequences that are 5' to the s gamma 1 region, which directly implicates the functional importance of 5' switch region flanking sequences in the control of class switch recombination.
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.
TLDR
The gene encoding activation-induced cytidine deaminase (AID) was isolated from a murine B cell lymphoma line, CH12F3-2, induced by combined stimulation of TGF-beta, IL-4, and CD40L and RT-PCR analysis of 15 human tissues showed that AID mRNA is expressed strongly in lymph nodes and tonsils.
Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions.
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.
TLDR
Results suggest that I.29 cells switch specifically to IgA, IgE or IgG2a due to the activation of the corresponding H chain constant region genes in IgM+ cells prior to the actual switch recombination event.
...
1
2
3
4
5
...