Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
@article{Muramatsu2000ClassSR, title={Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme}, author={M. Muramatsu and K. Kinoshita and S. Fagarasan and S. Yamada and Y. Shinkai and T. Honjo}, journal={Cell}, year={2000}, volume={102}, pages={553-563} }
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching from IgM to IgA without cytokine stimulation. AID deficiency caused a complete defect in class switching and showed a hyper-IgM phenotype with enlarged germinal centers containing strongly activated B cells before or after immunization. AID-/- spleen cells stimulated in vitro with LPS and cytokines failed to undergo class switch recombination although they expressed germline transcripts. Immunization of AID… CONTINUE READING
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References
SHOWING 1-10 OF 131 REFERENCES
Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)
- Biology, Medicine
- Cell
- 2000
- 1,485
- PDF
Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*
- Biology, Medicine
- The Journal of Biological Chemistry
- 1999
- 828
- PDF
Efficient recombination of a switch substrate retrovector in CD40-activated B lymphocytes: implications for the control of CH gene switch recombination.
- Biology, Medicine
- Journal of immunology
- 1998
- 32
High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells.
- Medicine, Biology
- International immunology
- 1996
- 194
- PDF
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
- Biology, Medicine
- Cell
- 1993
- 963
Somatic hypermutation in the heavy chain locus correlates with transcription.
- Biology, Medicine
- Immunity
- 1998
- 271
Shutdown of class switch recombination by deletion of a switch region control element
- Biology, Medicine
- Science
- 1993
- 347
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.
- Biology, Medicine
- Genomics
- 2000
- 148
Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions.
- Biology, Medicine
- Immunity
- 1998
- 68
- PDF
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.
- Medicine, Biology
- The EMBO journal
- 1986
- 318