Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy.

@article{Hamada1997ClassIA,
  title={Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy.},
  author={Mareomi Hamada and Yuji Shigematsu and Shuntaro Ikeda and Yuji Hara and Hideki Okayama and Kazuhisa Kodama and Takaaki Ochi and K. Hiwada},
  journal={Circulation},
  year={1997},
  volume={96 5},
  pages={1520-4}
}
BACKGROUND The class Ia antiarrhythmic drug disopyramide relieves the outflow tract obstruction of hypertrophic obstructive cardiomyopathy (HOCM). Disopyramide, however, has several adverse effects, such as dysuria and thirst, resulting from its anticholinergic activity. A new class Ia antiarrhythmic drug, cibenzoline, has little anticholinergic activity. The aim of this study is to elucidate whether cibenzoline attenuates left ventricular pressure gradient (LVPG) in patients with HOCM… CONTINUE READING
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