Class IV Semaphorins Promote Angiogenesis by Stimulating Rho-Initiated Pathways through Plexin-B

@article{Basile2004ClassIS,
  title={Class IV Semaphorins Promote Angiogenesis by Stimulating Rho-Initiated Pathways through Plexin-B},
  author={J. Basile and A. Barac and T. Zhu and K. Guan and J. Gutkind},
  journal={Cancer Research},
  year={2004},
  volume={64},
  pages={5212 - 5224}
}
The semaphorins are a large family of secreted and cell surface proteins that provide attractive and repulsive cues for axon guidance during neuronal development. Semaphorins share a conserved NH2-terminal Sema domain with their receptors, the plexins, which mediate neuronal cell adhesion, axon guidance, and maintenance of established neuronal pathways in the adult. Both semaphorins and plexins share structural homology with the extracellular domain of c-Met, a member of the scatter factor… Expand
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TLDR
It is demonstrated that a semaphorin, Sema4D, is angiogenic in vitro and in vivo and that this effect is mediated by its high-affinity receptor, Plexin B1, and it is proved that biologic effects elicited by PlexIn B1 require coupling and activation of the Met tyrosine kinase. Expand
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Semaphorins, a large family of membranebound and secreted proteins, signal through their transmembrane receptors, the plexins. Semaphorins and plexins share structural homologies with scatter factorExpand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
It is shown that SEMA4D production by head and neck carcinoma tumor cells induces expression of platelet-derived growth factor-B and angiopoietin-like protein 4 from endothelial cells in a Plexin-B1/Rho-dependent manner, thereby influencing proliferation and differentiation of pericytes and vascular permeability, whereas VEGF lacks these effects. Expand
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The Semaphorin 4D receptor controls invasive growth by coupling with Met
TLDR
In epithelial cells, Semaphorin 4D (Sema 4D) triggers invasive growth, a complex programme that includes cell–cell dissociation, anchorage-independent growth and branching morphogenesis, and the involvement of an unexpected signalling mechanism, namely, the coupling of a plexin to a tyrosine kinase receptor. Expand
Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho
TLDR
The findings that plexin-B signaling to the cytoskeleton is both Rac and Rho dependent form a starting point for unraveling the mechanism by which semaphorins and plexins control axon guidance and cell migration. Expand
Signalling by semaphorin receptors: cell guidance and beyond.
TLDR
This work has shown that plexins, alone, or in association with neuropilins, behave as fully functional semaphorin receptors, and their large cytoplasmic moiety is likely to trigger novel signal-transduction pathways. Expand
The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG
TLDR
The data in this report suggest that LARG plays a critical role in plexin-B1 signaling to stimulate Rho activation and cytoskeletal reorganization. Expand
Plexin-B1 Directly Interacts with PDZ-RhoGEF/LARG to Regulate RhoA and Growth Cone Morphology
TLDR
The study indicates that the interaction of mammalian plexin-B family members with the multidomain proteins PDZ-RhoGEF and LARG represents an essential molecular link between plex in-B and localized, Rho-mediated downstream signaling events which underly various plexIn-B-mediated cellular phenomena including axonal growth cone collapse. Expand
The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules
TLDR
The cloning and characterization of two sema genes in Drosophila, one in human, and the identification of two related viral sequences are reported, all of which encode proteins with conserved Semaphorin domains. Expand
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function
TLDR
During angiogenesis endothelial SEMA3 proteins endow the vascular system with the plasticity required for its reshaping by controlling integrin function. Expand
Semaphorin-mediated axonal guidance via Rho-related G proteins.
TLDR
There is intriguing new evidence that the Plexin receptors communicate directly with members of the Rho family GTPases, although uncertainties remain concerning how Plexins alter Rac1 function. Expand
Neuropilin Is a Semaphorin III Receptor
TLDR
It is reported that neuropilin, a type I transmembrane protein implicated in aspects of neurodevelopment, is a Sema III receptor and the identification of neuropILin-2, a related neuro pilin family member, is described. Expand
Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates
TLDR
It is concluded that plexins are receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion. Expand
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