Class IIa histone deacetylases: regulating the regulators

  title={Class IIa histone deacetylases: regulating the regulators},
  author={Maud Martin and Richard Kettmann and Franck Dequiedt},
In the last decade, the identification of enzymes that regulate acetylation of histones and nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in various cellular processes. Mammalian histone deacetylases (HDACs), which catalyse the removal of acetyl groups from lysine residues, are grouped into three classes, on the basis of similarity to yeast counterparts. An abundance of experimental evidence has established class IIa HDACs as crucial transcriptional… CONTINUE READING

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