Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis

@inproceedings{Clocchiatti2011ClassIH,
  title={Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis},
  author={Andrea Clocchiatti and Cristina Florean and Claudio Brancolini},
  booktitle={Journal of cellular and molecular medicine},
  year={2011}
}
Histone deacetylases (HDACs) are important regulators of gene expression. Specific structural features and distinct regulative mechanisms rationalize the separation of the 18 different human HDACs into four classes. The class II comprises a heterogeneous group of nuclear and cytosolic HDACs involved in the regulation of several cellular functions, not just limited to transcriptional repression. In particular, HDAC4, 5, 7 and 9 belong to the subclass IIa and share many transcriptional partners… CONTINUE READING