Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

  title={Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages},
  author={Jennifer L. Guerriero and Alaba Sotayo and Holly E. Ponichtera and Jessica A. Castrillon and Alexandra L. Pourzia and Sara E Schad and Shawn F. Johnson and Ruben D Carrasco and Suzan Lazo and Roderick T Bronson and Scott P. Davis and Mercedes Lobera and Michael A. Nolan and Anthony G. Letai},
Although the main focus of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and adaptive arms of the immune system might produce superior tumour reduction and elimination. Tumour-associated macrophages often have net pro-tumour effects, but their embedded location and their untapped potential provide impetus to discover strategies to turn them against tumours. Strategies that deplete (anti-CSF-1 antibodies and CSF-1R inhibition) or stimulate… 

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