Class III beta-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: analysis of NCIC JBR.10.

@article{Sve2007ClassIB,
  title={Class III beta-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: analysis of NCIC JBR.10.},
  author={Pascal S{\`e}ve and Raymond de Lai and Kuo-shun Ding and Timothy R Winton and Charles Butts and John Mackey and Charles Dumontet and Laith Dabbagh and Sarit Aviel-Ronen and Lesley Katie Seymour and Margaret Whitehead and Ming-Sound Tsao and Frances A. Shepherd and Tony Reiman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 3},
  pages={
          994-9
        }
}
PURPOSE High class III beta-tubulin (bTubIII) expression in advanced non-small cell lung cancer is known to correlate with reduced response rates and inferior survival with anti-microtubule agents. JBR.10 showed a 12% and 15% improvement in 5-year recurrence-free survival (RFS) and overall survival (OS), respectively, with the addition of cisplatin and vinorelbine following resection of stage IB-II non-small cell lung cancer. We sought to determine the effect of bTubIII on patient outcome and… CONTINUE READING
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