Class III actions in an experimental model of ventricular tachycardia.

@article{Brugada1993ClassIA,
  title={Class III actions in an experimental model of ventricular tachycardia.},
  author={Josep Brugada and Lucas V.A. Boersma and Francesc Navarro-L{\'o}pez and Maurits A. Allessie},
  journal={European heart journal},
  year={1993},
  volume={14 Suppl H},
  pages={
          50-5
        }
}
Simplified models of re-entry may help in our understanding of the electrophysiologic effects of class III drugs. In a model of re-entrant ventricular tachycardia around a ring of epicardium in Langendorff-perfused rabbit hearts, the electrophysiologic effects of class III antiarrhythmic drugs were studied and compared to those of class I drugs. Class III drugs were effective in terminating fast re-entrant ventricular tachycardias. Prolongation of the refractory period without affecting… CONTINUE READING

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