Corpus ID: 87519491

Class III PI3K-mediated prolonged activation of autophagy plays a critical role in the transition of cardiac hypertrophy to heart failure

@inproceedings{2015ClassIP,
  title={Class III PI3K-mediated prolonged activation of autophagy plays a critical role in the transition of cardiac hypertrophy to heart failure},
  author={丁正年 and 李跃华 and 吴军 and 刘莉 and 余鹏 and 张小进 and 高翔 and 涂飞 and 张阳阳 and 李传富 and 姜苏蓉},
  year={2015}
}
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The current progress and future potential of targeting the PI3K enzymes for therapeutic benefit in cardiovascular disease will be considered, while the challenges of developing drugs against these master cellular regulators will be discussed. Expand
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Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity
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The potential relationship between autophagic activity and cardiac metabolism is explored and how dysregulated autophagy leads to severe cardiac disorders from the perspective of metabolic control is discussed. Expand