Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

@article{Jaber2012ClassIP,
  title={Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function},
  author={Nadia Jaber and Zhixun Dou and Juei-suei Chen and Joseph M. Catanzaro and Yaping Jiang and Lisa M. Ballou and Elzbieta S Selinger and Xiaosen Ouyang and Richard Z Lin and Jianhua Zhang and Wei-Xing Zong},
  journal={Proceedings of the National Academy of Sciences},
  year={2012},
  volume={109},
  pages={2003 - 2008}
}
A critical regulator of autophagy is the Class III PI3K Vps34 (also called PIK3C3). Although Vps34 is known to play an essential role in autophagy in yeast, its role in mammals remains elusive. To elucidate the physiological function of Vps34 and to determine its precise role in autophagy, we have generated Vps34f/f mice, in which expression of Cre recombinase results in a deletion of exon 4 of Vps34 and a frame shift causing a deletion of 755 of the 887 amino acids of Vps34. Acute ablation of… 

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