Class III β-tubulin in normal and cancer tissues.

  title={Class III β-tubulin in normal and cancer tissues.},
  author={Marisa Mariani and Roshan Karki and Manuela Spennato and Deep Pandya and Shiquan He and Mirko Andreoli and Paul Fiedler and Cristiano Ferlini},
  volume={563 2},
Microtubules are polymeric structures composed of tubulin subunits. Each subunit consists of a heterodimer of α- and β-tubulin. At least seven β-tubulin isotypes, or classes, have been identified in human cells, and constitutive isotype expression appears to be tissue specific. Class III β-tubulin (βIII-tubulin) expression is normally confined to testes and tissues derived from neural cristae. However, its expression can be induced in other tissues, both normal and neoplastic, subjected to a… CONTINUE READING
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