Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.

@article{Venza2013ClassIH,
  title={Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.},
  author={Isabella Venza and Maria Visalli and Rosaria Oteri and Maria Paola Cucinotta and Diana Teti and Mario Venza},
  journal={Pigment cell & melanoma research},
  year={2013},
  volume={26 2},
  pages={193-204}
}
Here, we explored the effects of the novel class II-specific histone deacetylase inhibitors (HDACis) MC1568 and MC1575 on interleukin-8 (IL-8) expression and cell proliferation in cutaneous melanoma cell line GR-M and uveal melanoma cell line OCM-3 upon stimulation with phorbol 12-myristate 13-acetate (PMA). We found that PMA upregulated IL-8 transcription via the AP-1 binding site and identified c-Jun as the transcription factor involved in this eventS. MC1568 and MC1575 inhibited IL-8 levels… CONTINUE READING