Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle.

@article{Soos2001ClassIP,
  title={Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle.},
  author={Maria A. Soos and J\orgen Grue Jensen and Robert A.M. Brown and Stephen O'Rahilly and P. R. Shepherd and Jonathan Whitehead},
  journal={Archives of biochemistry and biophysics},
  year={2001},
  volume={396 2},
  pages={244-8}
}
While the role of the class IA phosphoinositide 3-kinase (PI 3-kinase) in insulin signaling is well established, little is known about the role of the class II PI 3-kinases. We show that insulin stimulation of intact rat soleus and epitrochlearis muscles causes a 3- to 4-fold increase in the activity of the wortmannin-resistant alpha isoform of the class II PI 3-kinase (PI3K-C2alpha). This activation is rapid and parallels the insulin-induced activation of the class IA PI 3-kinase associated… CONTINUE READING