Class II histone deacetylases: structure, function, and regulation.

  title={Class II histone deacetylases: structure, function, and regulation.},
  author={Nicholas Bertos and Andrew H-J Wang and Xiang Jiao Yang},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={79 3},
Acetylation of histones, as well as non-histone proteins, plays important roles in regulating various cellular processes. Dynamic control of protein acetylation levels in vivo occurs through the opposing actions of histone acetyltransferases and histone deacetylases (HDACs). In the past few years, distinct classes of HDACs have been identified in mammalian cells. Class I members, such as HDAC1, HDAC2, HDAC3, and HDAC8, are well-known enzymatic transcriptional corepressors homologous to yeast… CONTINUE READING