Class II histocompatibility antigen expression in human melanocytes transformed by Harvey murine sarcoma virus (Ha-MSV) and Kirsten MSV retroviruses

@article{Albino1986ClassIH,
  title={Class II histocompatibility antigen expression in human melanocytes transformed by Harvey murine sarcoma virus (Ha-MSV) and Kirsten MSV retroviruses},
  author={Anthony P. Albino and Alan N. Houghton and M. Eisinger and Janet S. Lee and Roman Kantor and Allen I. Oliff and L. John Old},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={164},
  pages={1710 - 1722}
}
Human melanocytes infected with Ki-MSV or Ha-MSV, but not amphotropic MuLV, undergo a series of transformation-related changes that are characteristic of malignant melanoma. These are (a) expression of Ia antigens, in particular DP, DQ, and DR class II histocompatibility gene products, (b) a transformed morphology and ability to grow in soft agar, and (c) a 5-10-fold increase in the cell surface expression of GD3 ganglioside. However, other characteristics of melanoma, such as independence from… CONTINUE READING
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