Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.

@article{Thayer1999ClassII,
  title={Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.},
  author={Wesley P. Thayer and Leszek Ignatowicz and Dominique A. Weber and Peter Egede Jensen},
  journal={Journal of immunology},
  year={1999},
  volume={162 3},
  pages={1502-9}
}
The class II-associated invariant chain peptide (CLIP) region of invariant chain (Ii) is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site. The role of the CLIP sequence was investigated by using mutant Ii molecules with altered affinity for the DR1 peptide-binding site. Both high- and low-affinity mutants were observed to efficiently assemble with DR1 and mediate transport to… CONTINUE READING

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