Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder.

@article{Foley2012ClassIH,
  title={Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder.},
  author={Andrew G. Foley and Shane Gannon and Nanette Rombach-Mullan and Alison Prendergast and Claire Barry and Andrew W. Cassidy and Ciaran M. Regan},
  journal={Neuropharmacology},
  year={2012},
  volume={63 4},
  pages={750-60}
}
In utero exposure of rodents to valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, has been proposed to induce an adult phenotype with behavioural characteristics reminiscent of those observed in autism spectrum disorder (ASD). We have evaluated the face validity of this model in terms of social cognition deficits which are a major core symptom of ASD. We employed the social approach avoidance paradigm as a measure of social reciprocity, detection of biological motion that is crucial… CONTINUE READING