Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression.

@article{Riddell1991ClassIM,
  title={Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression.},
  author={Stanley R Riddell and Mark Rabin and Adam P. Geballe and William J Britt and Philip D. Greenberg},
  journal={Journal of immunology},
  year={1991},
  volume={146 8},
  pages={2795-804}
}
The human pathogen CMV, is a major cause of morbidity and mortality in immunocompromised hosts. The CD8+ class I-restricted CTL response to CMV assists in preventing progression of CMV infection to life-threatening disease; however, the viral Ag recognized by CD8+ CTL are not well characterized. In general, virus-specific CTL recognize endogenously synthesized viral proteins processed and presented associated with class I MHC molecules. Although proteins or inactivated virions have been… CONTINUE READING

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