Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine‐Induced Cartilage Degradation

@article{Culley2013ClassIH,
  title={Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine‐Induced Cartilage Degradation},
  author={Kirsty L Culley and Wang Xu Hui and Matt J Barter and Rose Davidson and Tracey E. Swingler and Auriane P. M. Destrument and Jenny L Scott and Simon T Donell and Steve Fenwick and Andrew D Rowan and David A. Young and Ian M Clark},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 7},
  pages={
          1822-30
        }
}
OBJECTIVE To examine the ability of a broad-spectrum histone deacetylase (HDAC) inhibitor to protect cartilage in vivo, and to explore the effects of class-selective HDAC inhibitors and small interfering RNA (siRNA)-induced knockdown of HDACs on metalloproteinase expression and cartilage degradation in vitro. METHODS A destabilization of the medial meniscus (DMM) model was used to assess the in vivo activity of the HDAC inhibitor trichostatin A (TSA). Human articular chondrocytes (HACs) and… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 5 Excerpts
Highly Influenced

A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2009
View 4 Excerpts
Highly Influenced