Class I FIPs, Rab11-binding proteins that regulate endocytic sorting and recycling.


Rab11 GTPase is an important regulator of endocytic membrane traffic. In the GTP-bound form Rab GTPases interact with effector proteins and each Rab-effector complex is proposed to regulate a unique trafficking step/event such as vesicle docking, budding, transport, or fusion. At least six Rab11 effectors (family of Rab11 interacting proteins, FIPs) have… (More)