Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion.

@article{Sato2000ClassCV,
  title={Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion.},
  author={Trey K Sato and Peter Rehling and Michael R. Peterson and Scott D Emr},
  journal={Molecular cell},
  year={2000},
  volume={6 3},
  pages={661-71}
}
In yeast, the Class C Vps protein complex (C-Vps complex), composed of Vps11, Vps16, Vps18, and Vps33, functions in Golgi-to-vacuole protein transport. In this study, we characterized and purified this complex and identified its interaction with the syntaxin homolog Vam3. Vam3 pairs with the SNAP-25 homolog Vam7 and VAMP homolog Vti1 to form SNARE complexes during vesicle docking/fusion with the vacuole. The C-Vps complex does not bind to Vam3-Vti1-Vam7 paired SNARE complexes but instead binds… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2009
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