Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.

@article{Labont2007ClassBT,
  title={Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.},
  author={Eric D Labont{\'e} and Philip N. Howles and Norman A. Granholm and Juan Rojas and Joanna P. Davies and Yiannis A. Ioannou and David Y Hui},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1771 9},
  pages={1132-9}
}
Recent studies have documented the importance of Niemann-Pick C1-like 1 protein (NPC1L1), a putative physiological target of the drug ezetimibe, in mediating intestinal cholesterol absorption. However, whether NPC1L1 is the high affinity cholesterol binding protein on intestinal brush border membranes is still controversial. In this study, brush border membrane vesicles (BBMV) from wild type and NPC1L1-/- mice were isolated and assayed for micellar cholesterol binding in the presence or absence… CONTINUE READING