Class A scavenger receptor promotes cerebral ischemic injury by pivoting microglia/macrophage polarization.

@article{Qian2012ClassAS,
  title={Class A scavenger receptor promotes cerebral ischemic injury by pivoting microglia/macrophage polarization.},
  author={Lingling Qian and Guijuan Zong and Kefu Ma and X Zhu and H Zhang and Ning Li and Qiong Yang and Hui Bai and Jingjing Ben and X Li and Yiming Xu and Qiuyan Chen},
  journal={Neuroscience},
  year={2012},
  volume={218},
  pages={35-48}
}
Class A scavenger receptor (SR-A) is primarily expressed in microglia/macrophages and plays an important role in immune responses. However, whether SR-A can influence microglia/macrophage polarization in cerebral ischemic injury is not known. To this end we monitored the phenotypic alteration of microglia/macrophages in an animal model of cerebral ischemia injury. SR-A was up-regulated in mouse brains 24h after permanent occlusion of middle cerebral artery (MCAO). SR-A-deficient mice displayed… CONTINUE READING
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