Class A calcium channel variants in pancreatic islets and their role in insulin secretion.

@article{Ligon1998ClassAC,
  title={Class A calcium channel variants in pancreatic islets and their role in insulin secretion.},
  author={Brooke Ligon and Aubrey E. Boyd and Kathleen Dunlap},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 22},
  pages={13905-11}
}
The initiation of insulin release from rat islet beta cells relies, in large part, on calcium influx through dihydropyridine-sensitive (alpha1D) voltage-gated calcium channels. Components of calcium-dependent insulin secretion and whole cell calcium current, however, are resistant to L-type channel blockade, as well as to omega-conotoxin GVIA, a potent inhibitor of alpha1B channels, suggesting the expression of additional exocytotic calcium channels in the islet. We used a reverse transcription… CONTINUE READING

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