Class 1 Integrons, Gene Cassettes, Mobility, and Epidemiology

  title={Class 1 Integrons, Gene Cassettes, Mobility, and Epidemiology},
  author={Ad C. Fluit and F. J. Schmitz},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
 Integrons are genetic elements that, although unable to move themselves, contain gene cassettes that can be mobilized to other integrons or to secondary sites in the bacterial genome. The majority of approximately 60 known gene cassettes encode resistance to antibiotics. Recently, a number of gene cassettes encoding extended-spectrum β-lactamases or carbapenemases have been described. Up to at least five cassettes may be present in an integron, which leads to multiresistance. Frequently, more… CONTINUE READING
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