Claspin and Chk1 regulate replication fork stability by different mechanisms.

@article{Scorah2009ClaspinAC,
  title={Claspin and Chk1 regulate replication fork stability by different mechanisms.},
  author={Jennifer Scorah and Clare H. McGowan},
  journal={Cell cycle},
  year={2009},
  volume={8 7},
  pages={1036-43}
}
The checkpoint mediator protein Claspin facilitates the phosphorylation and activation of Chk1 by ATR and thus is required for efficient DNA replication. However, the physical association of Claspin homologues with replication factors and forks suggests that it might have additional functions in controlling DNA replication. DNA combing was used to examine the functions of Chk1 and Claspin at individual forks and to determine whether Claspin functions independently of Chk1. We find that Claspin… CONTINUE READING

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