Clarithromycin is a potent inhibitor of tumor-induced angiogenesis

@article{Yatsunami1997ClarithromycinIA,
  title={Clarithromycin is a potent inhibitor of tumor-induced angiogenesis},
  author={Jun Yatsunami and Norio Turuta and Kyoko Wakamatsu and Nobuyuki Hara and Masaki Sunto-gun Shizuoka Kageyama},
  journal={Research in Experimental Medicine},
  year={1997},
  volume={197},
  pages={189-197}
}
We investigated the inhibitory effect of clarithromycin, a 14-membered ring macrolide antibiotic, on tumor-induced angiogenesis in vivo using a mouse dorsal air sac model. The inhibitory effect of clarithromycin was dose-dependent, and 100 mg/kg of clarithromycin administered intraperitoneally twice a day reduced the area of dense capillary network to about 30% that of the control. However, in concentrations up to 50 μM clarithromycin had no effect on lung cancer cells and human vascular… CONTINUE READING
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