Clarithromycin is a potent inhibitor of tumor-induced angiogenesis.

  title={Clarithromycin is a potent inhibitor of tumor-induced angiogenesis.},
  author={Jun Yatsunami and N Turuta and Kentaro Wakamatsu and Nobuyuki Hara and Shunji Hayashi},
  journal={Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie},
  volume={197 4},
We investigated the inhibitory effect of clarithromycin, a 14-membered ring macrolide antibiotic, on tumor-induced angiogenesis in vivo using a mouse dorsal air sac model. The inhibitory effect of clarithromycin was dose-dependent, and 100 mg/kg of clarithromycin administered intraperitoneally twice a day reduced the area of dense capillary network to about 30% that of the control. However, in concentrations up to 50 microM clarithromycin had no effect on lung cancer cells and human vascular… CONTINUE READING


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