Clarithromycin increases neuronal excitability in CA3 pyramidal neurons through a reduction in GABAergic signaling.

Abstract

Antibiotics are used in the treatment and prevention of bacterial infections, but effects on neuron excitability have been documented. A recent study demonstrated that clarithromycin alleviates daytime sleepiness in hypersomnia patients (Trotti LM, Saini P, Freeman AA, Bliwise DL, García PS, Jenkins A, Rye DB. J Psychopharmacol 28: 697-702, 2014). To… (More)
DOI: 10.1152/jn.00134.2016

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Cite this paper

@article{Bichler2017ClarithromycinIN, title={Clarithromycin increases neuronal excitability in CA3 pyramidal neurons through a reduction in GABAergic signaling.}, author={Edyta K. Bichler and Courtney C. Elder and P. Speidel Garcia}, journal={Journal of neurophysiology}, year={2017}, volume={117 1}, pages={93-103} }