Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells

@inproceedings{Komatsu2012ClarithromycinEB,
  title={Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells},
  author={Seiichiro Komatsu and Keisuke Miyazawa and Shota Moriya and Aya Takase and Munekazu Naito and Masato Inazu and Norio Kohno and Masahiro Itoh and Akio Tomoda},
  booktitle={International journal of oncology},
  year={2012}
}
The specific 26S proteasome inhibitor, bortezomib (BZ) potently induces apoptosis as well as autophagy in metastatic breast cancer cell lines such as MDA-MB-231 and MDA-MB-468. The combined treatment of clarithromycin (CAM) and BZ significantly enhances cytotoxicity in these cell lines. Although treatment with up to 100 µg/ml CAM alone had little effect on cell growth inhibition, the accumulation of autophagosomes and p62 was observed… CONTINUE READING

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