Clarithromycin attenuates autophagy in myeloma cells.

@article{Nakamura2010ClarithromycinAA,
  title={Clarithromycin attenuates autophagy in myeloma cells.},
  author={Miki Nakamura and Yoshitaka Kikukawa and Motohiro Takeya and Hiroaki Mitsuya and Hiroyuki Hata},
  journal={International journal of oncology},
  year={2010},
  volume={37 4},
  pages={
          815-20
        }
}
It has been reported that clarithromycin (CAM) augments the anti-tumor activity of thalidomide against multiple myeloma (MM) cells, while the mechanism remains unclear. A myeloma cell line or primary myeloma cells were treated with CAM. Autophagy was analyzed by morphological changes, LC3 expression and lysotracker staining. CAM induced vacuoles in the cytoplasm of MM cells which resembled autolysosomes. The manifestation of the CAM-induced vacuoles was blocked by treatment with PI3-kinase… CONTINUE READING

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