Clarithromycin as a chiral selector for enantioseparation of basic compounds in nonaqueous capillary electrophoresis.

@article{Lebedeva2014ClarithromycinAA,
  title={Clarithromycin as a chiral selector for enantioseparation of basic compounds in nonaqueous capillary electrophoresis.},
  author={Margarita V Lebedeva and Aleksandra F Prokhorova and Elena N Shapovalova and Oleg A Shpigun},
  journal={Electrophoresis},
  year={2014},
  volume={35 19},
  pages={2759-64}
}
The first use of macrolide antibiotic clarithromycin (CLM) in nonaqueous media for enantioseparation (partial or baseline) of the following compounds: alprenolol, atenolol, metoprolol, clenbuterol, methoxyphenamine, pindolol, propranolol, sotalol, synephrine, labetalol, and fenoterol is reported. Each analysis took less than 15 min. To find optimal separation conditions, some properties of CLM (adsorption, solubility), as well as the effect of experimental parameters on the enantioseparation of… CONTINUE READING