Clarithromycin Inhibits Type A Seasonal Influenza Virus Infection in Human Airway Epithelial Cells

@article{Yamaya2010ClarithromycinIT,
  title={Clarithromycin Inhibits Type A Seasonal Influenza Virus Infection in Human Airway Epithelial Cells},
  author={Mutsuo Yamaya and Kyoko Shinya and Yukimasa Hatachi and Hiroshi Kubo and Masanori Asada and Hiroyasu Yasuda and Hidekazu Nishimura and Ryoichi Nagatomi},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2010},
  volume={333},
  pages={81 - 90}
}
Human influenza viruses attach to sialic acid with an α2,6linkage (SAα2,6Gal) on the airway epithelial cells, and the entry of the viruses into the cells and uncoating of the viruses require low pH of endosomes. Bafilomycin A1, a macrolide antibiotic and a specific inhibitor of vacuolar H+-ATPase, inhibits growth of type A and type B human influenza viruses in Madin-Darby canine kidney cells. However, the inhibitory effects of clinically used macrolide antibiotics on influenza virus infection… 
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Methods Citations
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Results Citations
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83 Citations

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Citation Type

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Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process
TLDR
The findings indicate the possibility that azithromycin could be an effective macrolide for the treatment of human influenza, and determine the anti-influenza A(H1N1)pdm09 virus activity of azathromycin, a re-positioned macrolides antibiotic with potential as a new anti- influenza candidate.
Serine Proteases and their Inhibitors in Human Airway Epithelial Cells: Effectson Influenza Virus Replication and Airway Serine Proteases and their Inhibitors in Human Airway Epithelial Cells: Effects on Influenza Virus Replication and Airway Inflammation
TLDR
Serine proteases expressed by human tracheal epithelial cells induce the proteolytic activation of influenza viruses and that serine protease inhibitors may reduce viral replication and the resultant production of inflammatory cytokines are suggested.
Leucomycin A3, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression
TLDR
LM-A3 showed effective action against influenza A virus infection with high anti-viral activity in human host cells, indicating the possibility that LM-A 3 is a prospective lead compound for the development of a drug for human influenza.
Efficacy of clarithromycin against H5N1 and H7N9 avian influenza a virus infection in cynomolgus monkeys.
Macrolide Therapy in Respiratory Viral Infections
TLDR
The properties of macrolides and their efficacy in various respiratory diseases, including rhinovirus, respiratory syncytial virus, and influenza virus are summarized.
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