Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives.

@article{Singh2016ClarificationTF,
  title={Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives.},
  author={Nripen Singh and Abhiram Arunkumar and Srinivas Chollangi and Zhijun George Tan and Michael C. Borys and Zheng Jian Li},
  journal={Biotechnology and bioengineering},
  year={2016},
  volume={113 4},
  pages={698-716}
}
Considerable progress has been made increasing productivity of cell cultures to meet the rapidly growing demand for antibody biopharmaceuticals through increased cell densities and longer culture times. This in turn has dramatically increased the burden of process and product related impurities on the purification processes. In addition, current trends in the biopharmaceutical industry point toward both increased productivity and targeting smaller patient populations for new indications. Taken… CONTINUE READING
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