Clarification of the identity of the mammalian fifth pharyngeal arch artery

  title={Clarification of the identity of the mammalian fifth pharyngeal arch artery},
  author={Simon D. Bamforth and Bill Chaudhry and Michael Bennett and Robert Wilson and Timothy J. Mohun and L H van Mierop and Deborah J. Henderson and Robert H. Anderson},
  journal={Clinical Anatomy},
The remodeling of the pharyngeal arch arteries is a complex process that occurs across vertebrates, although the specific number of arteries varies across species, with six in fish, but only five in birds and mammals, although they are numbered one through four, and six. The existence of a fifth arch artery in mammals has been debated for more than a century. Although some have doubted, and continue to doubt, its existence, several cardiovascular malformations can be explained only on the basis… 

How frequent is the fifth arch artery?

It is suggested that more convincing alternative explanations can be advanced to account for the majority of lesions currently interpreted on the basis of persistence of the arteries of the fifth arches, and appropriate description is important in terms of their classification.

Clarifying the anatomy of the fifth arch artery

A patient with tetralogy of Fallot and pulmonary atresia is presented, in whom the fifth arch artery provided a necessary communication between the ascending aorta and the pulmonary arteries, and the features are discussed to be essential before attaching the tag of "fifth arch artery" to a candidate vascular channel.

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It is suggested that the so-called “fifth arch arteries” are themselves then best explained either on the basis of existence of such collateral channels, or remodelling of the aortic sac, which is the manifold, during development, that gives rise to the pharyngeal arch arteries.

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It is argued that better alternative explanations can be offered to explain unusual branching of the extrapericardial arterial channels than presumed retention of the enigmatic arteries of the fifth pharyngeal arches, and it is of interest to chart the evidence provided by the authors to substantiate their claim.

How Should We Diagnose Persistence of the Artery of the Fifth Pharyngeal Arch?

An unequivocal example of double barreled aorta existing because of persistence of the artery of the left fifth pharyngeal arch is described, which had furthermore escaped detection for over three decades.

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Fifth Aortic Arch: Emperor's New Clothes?

Embryological development of the human cranio-facial arterial system: a pictorial review

The embryological development of the cranio-facial arterial vasculature from its beginning at approximately days 21–50 of intrauterine life is reviewed, with pictures illustrating each developmental phase.



Some Mice Feature 5th Pharyngeal Arch Arteries and Double-Lumen Aortic Arch Malformations

The results prove that some mice do develop a 5th pair of PAAs and show that malformations which occur rarely in humans and result from defective remodelling of the left 5th PAA can be identified in mice as well.

A fifth pharyngeal arch artery does not exist in rat.

The development of the caudal pharyngeal arch arteries was studied in perfused rat embryos in the interval of embryonic day 12 1/2 to embryonic day 13 3/4 using semithin serial sections and

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A muscularised pharynx, with skeletal support, serving the dual functions of feeding and respiration, is a fundamental vertebrate characteristic. Embryologically, the pharyngeal apparatus has its

Development of the pharyngeal arches

  • A. Graham
  • Medicine
    American journal of medical genetics. Part A
  • 2003
Pharyngeal arch development is more complex, and more consensual, than was previously believed.

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The formation and transformation of the pharyngeal arch arteries in the mouse embryo, from 8.5 to 13 days of gestation (DG), was observed using scanning electron microscopy of vascular casts and graphic reconstruction of 1‐µm serial epoxy‐resin sections to form an aortic‐arch system that was almost of the adult type.

Persistent 5th aortic arch--a great pretender: three new covert cases.

Persistent fifth aortic arch in man.

The present case is unique in at least three respects: lack of associated intracardiac malformation, the survival of the patient, and prenatal exposure to the possible teratogenic action of the anticonvulsant drug trimethadione (Tridione).

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Cardiovascular Development and Survival During Gestation in the Ts65Dn Mouse Model for Down Syndrome

Through the analysis of transmission rate and cardiovascular development in embryonic mice, more is learned about prenatal mortality and the origins of cardiac abnormality in the Ts65Dn mice to assist in understanding cardiovascular malformation associated with DS.

The Atlas of Mouse Development

Assessment of Developmental Stage of Pre- and Postimplantation Mouse Embryos Based on the Staging System of Theiler (1989) and general Observations on the Urogenital Ridges, Gonads, and Genital Duct System.