Clarification of the identity of the mammalian fifth pharyngeal arch artery

@article{Bamforth2013ClarificationOT,
  title={Clarification of the identity of the mammalian fifth pharyngeal arch artery},
  author={Simon D. Bamforth and Bill Chaudhry and Michael Bennett and Robert Wilson and Timothy J. Mohun and L H van Mierop and Deborah J. Henderson and Robert H. Anderson},
  journal={Clinical Anatomy},
  year={2013},
  volume={26}
}
The remodeling of the pharyngeal arch arteries is a complex process that occurs across vertebrates, although the specific number of arteries varies across species, with six in fish, but only five in birds and mammals, although they are numbered one through four, and six. The existence of a fifth arch artery in mammals has been debated for more than a century. Although some have doubted, and continue to doubt, its existence, several cardiovascular malformations can be explained only on the basis… 
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References

SHOWING 1-10 OF 26 REFERENCES
Some Mice Feature 5th Pharyngeal Arch Arteries and Double-Lumen Aortic Arch Malformations
TLDR
The results prove that some mice do develop a 5th pair of PAAs and show that malformations which occur rarely in humans and result from defective remodelling of the left 5th PAA can be identified in mice as well.
A fifth pharyngeal arch artery does not exist in rat.
The development of the caudal pharyngeal arch arteries was studied in perfused rat embryos in the interval of embryonic day 12 1/2 to embryonic day 13 3/4 using semithin serial sections and
The development and evolution of the pharyngeal arches
A muscularised pharynx, with skeletal support, serving the dual functions of feeding and respiration, is a fundamental vertebrate characteristic. Embryologically, the pharyngeal apparatus has its
Development of the pharyngeal arches
  • A. Graham
  • Medicine
    American journal of medical genetics. Part A
  • 2003
TLDR
Pharyngeal arch development is more complex, and more consensual, than was previously believed.
Development of pharyngeal arch arteries in early mouse embryo
TLDR
The formation and transformation of the pharyngeal arch arteries in the mouse embryo, from 8.5 to 13 days of gestation (DG), was observed using scanning electron microscopy of vascular casts and graphic reconstruction of 1‐µm serial epoxy‐resin sections to form an aortic‐arch system that was almost of the adult type.
Persistent Left Fifth Aortic Arch Associated with Tetralogy of Fallot
TLDR
The left aortic arch in this case was not a source of pulmonary circulation, as described in previous cases with pulmonary atresia and ventricular septal defect, but was a systemic-to-systemic connection without functional relevance.
Persistent fifth aortic arch in man.
TLDR
The present case is unique in at least three respects: lack of associated intracardiac malformation, the survival of the patient, and prenatal exposure to the possible teratogenic action of the anticonvulsant drug trimethadione (Tridione).
A persistent fifth aortic arch in man: A double-lumen aortic arch (presentation of a new case and review of the literature)
TLDR
Evidence supporting derivation of the inferior channel of the DLAA from the embryologic fifth aortic arch is discussed, which indicates relatively frequent association of DLAA with preductal coarctation ofThe aorta.
Cardiovascular Development and Survival During Gestation in the Ts65Dn Mouse Model for Down Syndrome
TLDR
Through the analysis of transmission rate and cardiovascular development in embryonic mice, more is learned about prenatal mortality and the origins of cardiac abnormality in the Ts65Dn mice to assist in understanding cardiovascular malformation associated with DS.
The Atlas of Mouse Development
TLDR
Assessment of Developmental Stage of Pre- and Postimplantation Mouse Embryos Based on the Staging System of Theiler (1989) and general Observations on the Urogenital Ridges, Gonads, and Genital Duct System.
...
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